Wang Lab at PSU
Epigenetic Histone Modifications in Cell Differentiation and Cancer
Publications from Penn State
Wang Y *, Li P*, Wang S*, Hu J, Chen XA, Wu J, Fisher M, Oshaben K, Zhao N, Gu Y, Chen G#, Wang Y#. (2012) Anticancer PAD inhibitors regulate autophagy and the mammalian target of rapamycin complex 1 activity. Journal of Biological Chemistry. 287:25941-53. (*authors of equal contribution, # authors of correspondence)
Hu J*, Yao H*, Gan F, Tokarski A, and Wang Y. (2012) Coordination of OKL38 and p53 in apoptosis induction by regulating mitochondria morphology and function. PLoS ONE 7(8):e43362. (*authors of equal contribution).
Leshner M, Wang S, Lewis C, Zheng H, Chen XA,Santy L, and Wang Y. (2012) PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures. Frontiers in Immunology 3:307.
Xu L, Hu J, Zhao Y, Hu J, Xiao J, Wang Y, Ma D, and Chen Y. (2012) PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway. Apoptosis 17:1235-1245.
Shi K, Edwards PS, Hu J, Xu Q, Wang Y, Psaltis D, and Liu Z. (2012) Holographic coherent anti-stokes raman scattering bio-imaging. Biomedical Optics Express 3:1744-1749.
Li P, Hu J, and Wang Y. (2012) Methods for analyzing histone citrullination in chromatin structure and gene regulation. Methods in Molecular Biology 809:473-488.
Wu L, Zee BM, Wang Y, Garcia BA, and Dou Y. (2011) The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 ubiquitylation and is important for H3 K4/K79 methylation and transcription activation. Molecular Cell 43:132-144.
Wu H, Zeng H, Lam R, Tempel W, Amaya MF, Xu C, Dombrovski L, Qiu W, Wang Y, and Min J. (2011) Structural and histone binding ability characterizations of human PWWP domains. PloS ONE 6(6): e18919.
Liu Y, Chan YM, Wu J, Chen C, Benesi A, Hu J, Wang Y, and Chen G. (2011) Chemical Synthesis of a bisphosphorylated mannose-6-phosphate N-glycan and its facile monoconjugation with human carbonic anhydrase II for in vivo fluorescence imaging. Chembiochem. 12:685-690.
Joo HY, Jones A, Yang C, Zhai L, Smith AD, Zhagn Z, Chandrasekharan MB, Sun ZW, Renfrow M, Wang Y, Chang C, and Wang H. (2011) Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. Journal of Biological Chemistry 286:7190-7201.
Li P, Li M, Lindberg MR, Kennett MJ, Xiong N, and Wang Y. (2010) PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. Journal of Experimental Medicine 207:1853-62.
Li P, Wang D, Yao H, Doret P, Hao G, Shen Q, Qiu H, Zhang X, Wang Y, Chen G, and Wang Y. (2010) Coordination of PAD4 and HDAC2 in the regulation of p53 target gene expression. Oncogene 29:3153-62.
Jin Y, Xia M, Saylor CM, Narayan K, Kang J, Wiest DL, Wang Y, and Xiong N. (2010) Intrinsic programming of thymic T cells for specific peripheral tissue localization. Journal of Immunology. 185:7156-7160.
Chow, O.A., von Kockritz-Blickwede, M., Bright, A.T., Hensler, M.E., Zinkernagel, A.S., Cogen, A.L., Gallo, R.L., Monestier, M., Wang, Y., Glass, C.K., and Nizet, V. (2010) Statins enhance formation of phagocyte extracellular traps. Cell Host & Microbe 18:445-454.
Wang Y*, Li M, Stadler S, Correll S, Li P, Wang D, Hayama R, Leonelli L, Han H, Grigoryev S, Allis CD, and Coonrod SA* (2009) Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. Journal of Cell Biology 184:205-13. (*correspondence authors).
Hao G, Wang D, Gu J, Shen Q, Gross SS, and Wang Y. (2009) Neutral loss of isocyanic acid in peptide CID spectra: a novel diagnostic marker for mass spectrometry identification of protein citrullination. Journal of American Society of Mass Spectrometry. 20:723-7.
Prior to 2008
Li P, Yao H, Zhang Z, Li M, Luo Y, Thompson PR, Gilmour DS, and Wang Y. (2008) Regulation of p53 target gene expression by peptidylarginine deiminase 4. Molecular and Cellular Biology 28:4745-58.
Yao H, Li P, Venters BJ, Zheng S, Thompson PR, Pugh BF, and Wang Y. (2008) Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. Journal of Biological Chemistry 283:20060-8.
Wang, Y. (2006) Methylation and demethylation of histone Lys and Arg residues in chromatin structure and function. In the ENZYMES protein methyltransferases XXIV, 123-153.
Publications of postdoctoral work
Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD*, and Coonrod SA*. (2004) Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 306:279-83. (*correspondence authors; cited 438 times)
Wang Y, Wysocka J, Perlin JR, Leonelli L, Allis CD, and Coonrod SA. (2004) Linking histone modifications to epigenetics: the rigidity and plasticity of the marks. The 69th Cold Spring Harbor Symposium on Quantitative Biology, 161-170.
Wang Y, Fischle W, Cheung W, Jacobs S, Khorasanizadeh S, and Allis CD. (2004) Beyond the double helix: writing and reading the histone code. In: Reversible protein acetylation. Novartis Found Symp, 259:3-20 Wiley, Chichester.
Sarmento OF, Digilio LC, Wang Y, Perlin J, Herr JC, Allis CD, and Coonrod, SA. (2004) Dynamic alterations of specific histone modifications during early murine development. J Cell Sci. 117:4449-59.
Barber CM, Turner FB, Wang Y, Hagstrom K, Taverna SD, Mollah S, Ueberheide B, Meyer BJ, Hunt DF, Cheung P, and Allis CD. (2004) The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved. Chromosoma 112:360-71.
Fischle W*, Wang Y*, Jacobs SA*, Kim Y, Allis CD, and Khorasanizadeh S. (2003) Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by polycomb and HP1 chromodomains. Genes Dev. 17:1870-81. (*authors of equal contribution)
Fischle W, Wang Y, and Allis CD. (2003) Binary switches and modification cassettes in histone biology and beyond. Nature 425:475-9.
Fischle W*, Wang Y*, and Allis CD. (2003) Histone and Chromatin Cross-talk. Curr. Opin. Cell Biol. 15:172-83. (*authors of equal contribution)
Nishioka K, Rice JC, Sarma K, Erdjument-Bromage H, Werner J, Wang Y, Chuikov S, Valenzuela P, Tempst P, Steward R, Lis JT, Allis CD, and Reinberg D. (2002) PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol. Cell 9:1201-13.
Publications of graduate work
Wang Y, Zhang W, Jin Y, Johansen J, and Johansen KM. (2001) The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell 105:433-43.
Bao X, Zhang W, Krencik R, Deng H, Wang, Y, Girton J, Johansen J, and Johansen KM. (2005) The JIL-1 kinase interacts with lamin Dm0 and regulates nuclear lamina morphology of Drosophila nurse cells. J. Cell Sci. 118:5079-87.
Zhang W, Wang Y, Long J, Girton J, Johansen J, and Johansen KM. (2003) A developmentally regulated splice-variant from the complex lola locus encoding multiple different zinc-finger domain proteins interacts with the chromosomal kinase JIL-1. J. Biol. Chem. 278:11696-704.
Jin Y *, Wang Y *, Johansen J, and Johansen KM. (2000) JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the MSL dosage compensation complex. J. Cell Biol. 149:1005-10. (*authors of equal contribution)
Walker DL, Wang D, Jin Y, Rath U, Wang Y, Johansen J, and Johansen KM. (2000) Skeletor, a novel chromosomal protein that redistributes during mitosis provides evidence for the formation of a spindle matrix. J. Cell Biol. 151:1401-12.
Jin Y, Wang Y, Walker DL, Dong H, Conley C, Johansen J, and Johansen KM. (1999) JIL-1: A novel chromosomal tandem kinase implicated in transcriptional regulation in Drosophila. Mol. Cell 4:129-35.
Johansen KM, Johansen J, Jin Y, Walker DL, Wang D, and Wang Y. (1999) Chromatin structure and nuclear remodeling. Crit Rev Eukaryot Gene Expr. 9:267-77.